The Ice-Caps
Does Al Gore really believe in catastrophic global warming? Since Al Gore was offered the opportunity (in person) to facilitate serious debate on the underlying science of global climate change, 11 months, 2 weeks, 2 days, 5 hours, 43 minutes, and 37 seconds have elapsed.
Despite milking lucrative speaking engagements and book deals with his global warming shtick he declines any such debate.
Challenge issued to environmental journalists and advocates of catastrophic AGW (Anthropogenic Global Warming)
Spinning Global Warming
How To Solve Global Warming
UNEP warns of ‘planet spinning
David Corn
The Death of Environmentalism
Spinning science for profit and power
Meltdown: The Predictable Distortion of Global Warming by Scientists, Politicians, and the Media
Why Global Warming
Spinning us to war in Iran
Is global warming a bigger threat than terrorism?
Global Warming from a Scientific Perspective
From the Desert to the Sea
Global Warming Skeptics Engage In Denial And Spin Over New Academy Report; Gore Responds
Message From Katrina: Code Red for Global Warming
The piece on global warming?
Global warming is real
Al Gore Pushes Politicians for 'Climate Crisis' Action
Effects of hyperthermia on intracellular chloride.
The hypothalamus is the part of the brain that controls metabolic activities and reproductive functions
Brain serotonin depletion attenuates heatstroke-induced cerebral ischemia and cell
Heatstroke (or hyperthermia) is the primary cause of death from Ecstasy
Ecstasy
Circulating angiotensin-converting enzyme, von Willebrand factor antigen and thrombomodulin in exertional heat stroke.
Heat stroke
One of the primary cardiovascular adjustments to hyperthermia is a sympathetically mediated increase in vascular resistance in the viscera. Nonneural factors such as a change in vascular tone or reactivity may also contribute to this response.
Modulation of temperature-induced tone by vasoconstrictor agents
The old wives' tale that heat relieves abdominal pain, such as colic or menstrual pain, has been scientifically proven by a UCL (University College London) scientist, who will presented the findings at the Physiological Society's annual conference hosted by UCL.
"The heat doesn't just provide comfort and have a placebo effect - it actually deactivates the pain at a molecular level in much the same way as pharmaceutical painkillers work. We have discovered how this molecular process works."
If heat over 40 degrees Celsius is applied to the skin near to where internal pain is felt, it switches on heat receptors located at the site of injury. These heat receptors in turn block the effect of chemical messengers that cause pain to be detected by the body.
The team found that the heat receptor, known as TRPV1, can block P2X3 pain receptors. These pain receptors are activated by ATP, the body's source of energy, when it is released from damaged and dying cells. By blocking the pain receptors, TRPV1 is able to stop the pain being sensed by the body.
Dr King added: "The problem with heat is that it can only provide temporary relief. The focus of future research will continue to be the discovery and development of pain relief drugs that will block P2X3 pain receptors. Our research adds to a body of work showing that P2X3 receptors are key to the development of drugs that will alleviate debilitating internal pain."
Scientists made this discovery using recombinant DNA technology to make both heat and pain receptor proteins in the same host cell and watching the molecular interactions between the TRPV1 protein and the P2X3 protein, switched on by capsaicin, the active ingredient in chilli, and ATP, respectively.
Heat Halts Pain Inside The Body
TRPV3 is indeed a temperature sensor
The human brain is like a general in a bunker. Floating in its bubble of cerebrospinal fluid, it has no direct window to the outside world, so the only way for the brain to observe, comprehend, and order the body into action is to rely on information it receives. This information comes to it through a sophisticated system of sensory neurons that connect the brain to organs like the eye, ear, nose, and mouth.
mice lacking the TRPV3 protein have specific deficiencies in their ability to detect temperatures.
Molecular thermometers on skin cells detect heat and camphor
Heating up
The idea of prescribing heat, or hyperthermia, to cure whatever ails you spans hundreds of years, says cancer researcher Donald Coffey of Johns Hopkins University in Baltimore. "There's no culture in the world that doesn't believe that hot springs and baths are good for you," he adds.
Almost a century later, in the 1970s and 1980s, researchers renewed attempts to kill tumors by heating them with microwaves, ultrasound, or other methods. "We had our sights set on killing tumor cells directly to make hyperthermia effective," says radiation biologist Mark Dewhirst of Duke University Medical Center in Durham, N.C.
As researchers developed more-accurate ways to measure internal temperature, they made a surprising discovery. "We found out that temperatures too low to kill cells were quite effective in sensitizing tumors" to other treatments, Dewhirst says. Temperatures that were a mere 2°C to 9°C warmer than body temperature could make a difference for cancer treatments
Heat also deforms the vast array of proteins necessary for normal cellular functions, explains radiologist Joseph Roti Roti of Washington University in St. Louis. Some proteins bend when warmed, exposing molecular segments that stick to other proteins. "This is like putting rust in the machinery," he says.
Hotter temperatures also seem to have a dramatic effect on the immune system, says immunologist Elizabeth Repasky of Roswell Park Cancer Institute in Buffalo, N.Y. Studies in her lab and elsewhere' have shown that fever-range temperatures increase the infection-fighting ferocity of immune components such as dendritic cells and macrophages. Such an increase in immune power could also potentially fight off tumors, Repasky says.
Warming Up to Hyperthermia
Despite milking lucrative speaking engagements and book deals with his global warming shtick he declines any such debate.
Challenge issued to environmental journalists and advocates of catastrophic AGW (Anthropogenic Global Warming)
Spinning Global Warming
How To Solve Global Warming
UNEP warns of ‘planet spinning
David Corn
The Death of Environmentalism
Spinning science for profit and power
Meltdown: The Predictable Distortion of Global Warming by Scientists, Politicians, and the Media
Why Global Warming
Spinning us to war in Iran
Is global warming a bigger threat than terrorism?
Global Warming from a Scientific Perspective
From the Desert to the Sea
Global Warming Skeptics Engage In Denial And Spin Over New Academy Report; Gore Responds
Message From Katrina: Code Red for Global Warming
The piece on global warming?
Global warming is real
Al Gore Pushes Politicians for 'Climate Crisis' Action
Effects of hyperthermia on intracellular chloride.
The hypothalamus is the part of the brain that controls metabolic activities and reproductive functions
Brain serotonin depletion attenuates heatstroke-induced cerebral ischemia and cell
Heatstroke (or hyperthermia) is the primary cause of death from Ecstasy
Ecstasy
Circulating angiotensin-converting enzyme, von Willebrand factor antigen and thrombomodulin in exertional heat stroke.
Heat stroke
One of the primary cardiovascular adjustments to hyperthermia is a sympathetically mediated increase in vascular resistance in the viscera. Nonneural factors such as a change in vascular tone or reactivity may also contribute to this response.
Modulation of temperature-induced tone by vasoconstrictor agents
The old wives' tale that heat relieves abdominal pain, such as colic or menstrual pain, has been scientifically proven by a UCL (University College London) scientist, who will presented the findings at the Physiological Society's annual conference hosted by UCL.
"The heat doesn't just provide comfort and have a placebo effect - it actually deactivates the pain at a molecular level in much the same way as pharmaceutical painkillers work. We have discovered how this molecular process works."
If heat over 40 degrees Celsius is applied to the skin near to where internal pain is felt, it switches on heat receptors located at the site of injury. These heat receptors in turn block the effect of chemical messengers that cause pain to be detected by the body.
The team found that the heat receptor, known as TRPV1, can block P2X3 pain receptors. These pain receptors are activated by ATP, the body's source of energy, when it is released from damaged and dying cells. By blocking the pain receptors, TRPV1 is able to stop the pain being sensed by the body.
Dr King added: "The problem with heat is that it can only provide temporary relief. The focus of future research will continue to be the discovery and development of pain relief drugs that will block P2X3 pain receptors. Our research adds to a body of work showing that P2X3 receptors are key to the development of drugs that will alleviate debilitating internal pain."
Scientists made this discovery using recombinant DNA technology to make both heat and pain receptor proteins in the same host cell and watching the molecular interactions between the TRPV1 protein and the P2X3 protein, switched on by capsaicin, the active ingredient in chilli, and ATP, respectively.
Heat Halts Pain Inside The Body
TRPV3 is indeed a temperature sensor
The human brain is like a general in a bunker. Floating in its bubble of cerebrospinal fluid, it has no direct window to the outside world, so the only way for the brain to observe, comprehend, and order the body into action is to rely on information it receives. This information comes to it through a sophisticated system of sensory neurons that connect the brain to organs like the eye, ear, nose, and mouth.
mice lacking the TRPV3 protein have specific deficiencies in their ability to detect temperatures.
Molecular thermometers on skin cells detect heat and camphor
Heating up
The idea of prescribing heat, or hyperthermia, to cure whatever ails you spans hundreds of years, says cancer researcher Donald Coffey of Johns Hopkins University in Baltimore. "There's no culture in the world that doesn't believe that hot springs and baths are good for you," he adds.
Almost a century later, in the 1970s and 1980s, researchers renewed attempts to kill tumors by heating them with microwaves, ultrasound, or other methods. "We had our sights set on killing tumor cells directly to make hyperthermia effective," says radiation biologist Mark Dewhirst of Duke University Medical Center in Durham, N.C.
As researchers developed more-accurate ways to measure internal temperature, they made a surprising discovery. "We found out that temperatures too low to kill cells were quite effective in sensitizing tumors" to other treatments, Dewhirst says. Temperatures that were a mere 2°C to 9°C warmer than body temperature could make a difference for cancer treatments
Heat also deforms the vast array of proteins necessary for normal cellular functions, explains radiologist Joseph Roti Roti of Washington University in St. Louis. Some proteins bend when warmed, exposing molecular segments that stick to other proteins. "This is like putting rust in the machinery," he says.
Hotter temperatures also seem to have a dramatic effect on the immune system, says immunologist Elizabeth Repasky of Roswell Park Cancer Institute in Buffalo, N.Y. Studies in her lab and elsewhere' have shown that fever-range temperatures increase the infection-fighting ferocity of immune components such as dendritic cells and macrophages. Such an increase in immune power could also potentially fight off tumors, Repasky says.
Warming Up to Hyperthermia
posted by Andy at 2:42 PM
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